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Beilstein J. Org. Chem. 2022, 18, 174–181, doi:10.3762/bjoc.18.19
Graphical Abstract
Figure 1: Naturally occurring HDAC inhibitors.
Figure 2: Naturally occurring HDAC inhibitors with different zinc-binding motifs.
Scheme 1: Planned syntheses of Cyl-1 derivatives.
Scheme 2: Cyl-1 derivatives via peptide Claisen rearrangement.
Scheme 3: Synthesis of tetrapeptide allyl esters 8.
Scheme 4: Synthesis and late stage modifications of Cyl derivatives.
Beilstein J. Org. Chem. 2012, 8, 1652–1656, doi:10.3762/bjoc.8.189
Figure 1: Bottromycins.
Scheme 1: Syntheses of endothiopeptides by thio-Ugi reaction.
Scheme 2: Synthesis of amidine 5 by thio-Ugi reaction.
Scheme 3: Synthesis of the bottromycin ring system 12 by thio-Ugi reaction.
Beilstein J. Org. Chem. 2011, 7, 1299–1303, doi:10.3762/bjoc.7.151
Scheme 1: Passerini reactions of α,β-unsaturated aldehyde 5.
Scheme 2: Passerini and Ugi reaction of saturated aldehyde 7.